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    2022-09-29 00:40:24÷˹ҽѧ
    ʾʹŴԺܴʹķйأܺܶصӰ죬Ŵֻе֮һ

    ʹΪһִлԼߣʹҲԽԽᣬԭġ겡ڡСӡҲúܳ Ůʹı151صġŮ

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    ͬһʹ磬Ҳǡ磺

    ʹŴ

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    ʹҩӰ

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    ˵ʹӦһЩʲô

    01

    ʹŴ

    ԭʹŴԣǺͷʹмۼ

    ǣʹŴԺܴʹķйأܺܶصӰ죬Ŵֻе֮һ

    ԭʹ磬Ŵֻͨ1%-2%ҡ

    ̷ʹDzŴġ

    ʹԭԴ೬л¡

    ЩŴأ

    1ŴȱݵʴлңϳʵøǿʷֽøܼͣԴɹർʹ硣

    2תͨ·Ե׽ṹ쳣й½ڵʹ硣

    3һЩŴԼͨͬ;̷ʹ磬磺ԭۻۺ

    ܽ᣺Ŵǿأءϰߡλȡ

    ʹ粡ȫȨҲӰķ

    һ¶һһ̣ʹ粻谭һء

    02

    ʹӰ

    ԣʹԵԹܼûвӰ졣ʹҩҪлųҺųһ㲻ԵֳӰ졣Ůԣвѧо֤ʵʹŮвΪ 0.04-5%ҴŮڸ֮ԴǶڵŮԵʹĸʻǺܵ͵ġ

    ŮԵʹӰĿǰڵʹں̫Сû㹻ٴ˵ʹӰ졣ǸеŮʹ综ҽȷ£ܹӤǶŮʹ综ڻڼ丶ĿҪ˶ܶࡣڻڼǻ˥ߡˮڼ֬εȲ֢ķձȳࡣһҪϧǸΪһŮʹ综ߣǸԶĶ࣡

    03

    ʹҩӰ

    ʹ缱ԷڵҪԿֹʹΪ忹ҩˮɼƤʼҩ

    ֹʹҩкӰأ

    *ڣNSAIDsFDAҩB࣬ǰ3ʹNSAIDs̥/ķգһ㽨ʱӦʹá

    *ڣʹNSAIDsʱҽָ½ʹãӦѡѡԡ˥ڶ̵ҩơҵȣЧӦNSAIDsɽͶ̥ķաʱͣҩ

    ˮɼкӰ죿

    ˮɼʹ缱ԷЧҩFDAҩD࣬ϸ˿ѣŮڲʹáҲоʾˮɼӦöŮȷĸӰ죬ʹ综߱ڼɿʹСƷÿ1-2ΣÿһƬСƷ

    ƤʼضкӰ죿

    *ƤʼFDAҩBࣨЧɣCࣨЧɣĿǰȱƤʼضӰֱ֤ݡдƤʼضӰоʾƤʼûֱӰ졣ԿƼʹ综ڼԷڰСЧãʱͣҩ

    ܵ˵бмƻԻŮԶܹҽʦõһݼЧƷ

    04

    ʹ绨Σ

    ƻѴһԻرܵ⡣ʹƾѼأ

    ʹҩﲢᵽˮɼDz˾¡ͼҩﲢԴͥɺܴĸ

    Ѵ0.1g/Ƭ0.7~1ԪһƬÿ2~3Ƭ

    Dz˾40mg/Ƭ1.5~2ԪһƬÿ80mg

    ˮɼ1mg/Ƭ0.7~0.8Ԫ/ƬǼÿ1Ƭ

    ϼ۸ο򡢲˸廯ҩȱ仯

    һ127ߵͳݱʹ综߰ҩƷãƽһܻԼΪ8000ԪƽһΪ667Ԫ

    05

    ˵ʹӦһЩʲô

    Ȼ㰮ǸtaЯһ·ǿһЩʲôǸtaأ

    ʹ粡˲̽ϳԼҩƵľѹϸʳжӰʹ粡˵״߼Ӧܶĺͻ߰ע⻼仯οȰ⻼ߣսʤġԵһʹ综ߵʱҪǼලʳ˶ˮʽᡣֻҪ֣ήʹҲͺٻᷢ

    ʳʹӦٺͼලߺʳӦʳѡʳ

    һdzʳʹ͸Ѫ֢ĻӦȫЩʳֶࣻˮƷŨŨʻȡ

    ڶиʳӦϸڼԷڲʳá⣻⣻ࣻ׿࣬иɶࡣ 

    еʺʳɫ۾Ҷ߲ˣ߲ˣ۶߲ˣδƵľࣻˮࡣ 

    ǵʺʳ˼ʺֵࣻࣻdzɫҶˣ߲ˣѹ߲ˣ߲ˣˮʳ

    ̵ĻߣӦලʹ综߽̽ơͬʱԺͻһ˶˯ڡһ԰߻ⲡ飬һ潡ʽҲԴáһõϰߣһ𽡿ϣӦеһ˺˰ɡ

    ʹ粻Dzֻ֢֮Ҫ߼ƣעʳϸڣЧԤֹʹķͷչʹά͹߻ߵΪʹ综ߵһ룬Ѿһεǣta֣һС۰ɣ

    ο

    1.Ŵʹ/Ѫ֢Ӱij̽ű壬ЭҽѧԺ2013

    2.Tanya J. Major.et al. An update on the genetics of hyperuricaemia and gout. Nature Reviews Rheumatology. 14 341-353 (2018).

    3.Meng-tse Gabriel Lee.et al.Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility. Scientific Reports. 9 4981 (2019).

    4.ת˵ػ̬ԭʹŴ׸Թϵͷƺȣ㽭ҽѧ2017

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